YNL307C

From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YNL307C
Gene name MCK1
Aliases CMS1, YPK1
Feature type ORF, Verified
Coordinates Chr XIV:57573..56446
Primary SGDID S000005251


Description of YNL307C: Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family[1][2][3][4]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!




<protect>

References

See Help:References on how to add references

  1. Lim MY, et al. (1993) Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. J Biol Chem 268(28):21155-64 SGD PMID 8407952
  2. McQueen J, et al. (2012) The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division. Cell Cycle 11(18) SGD PMID 22918234
  3. Neigeborn L and Mitchell AP (1991) The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression. Genes Dev 5(4):533-48 SGD PMID 2010083
  4. Shero JH and Hieter P (1991) A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1). Genes Dev 5(4):549-60 SGD PMID 2010084

See Help:Categories on how to add the wiki page for this gene to a Category </protect>