YNL298W
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| Systematic name | YNL298W |
| Gene name | CLA4 |
| Aliases | ERC10 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:68915..71443 |
| Primary SGDID | S000005242 |
Description of YNL298W: Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p[1][2][3][4][5][6]
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References
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- Jump up ↑ Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 SGD PMID 19218422
- Jump up ↑ Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 SGD PMID 9271384
- Jump up ↑ Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 SGD PMID 14517318
- Jump up ↑ Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 SGD PMID 7649470
- Jump up ↑ Lin M, et al. (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37 SGD PMID 19793923
- Jump up ↑ Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 SGD PMID 14993234
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