YNL293W
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| Systematic name | YNL293W |
| Gene name | MSB3 |
| Aliases | GYP3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:80640..82541 |
| Primary SGDID | S000005237 |
Description of YNL293W: Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p[1][2][3][4]
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References
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- Jump up ↑ Albert S and Gallwitz D (1999) Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J Biol Chem 274(47):33186-9 SGD PMID 10559187
- Jump up ↑ Bach S, et al. (2000) Co-deletion of the MSB3 and MSB4 coding regions affects bipolar budding and perturbs the organization of the actin cytoskeleton. Yeast 16(11):1015-23 SGD PMID 10923023
- Jump up ↑ Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 SGD PMID 12913108
- Jump up ↑ Lachmann J, et al. (2012) The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell 23(13):2516-26 SGD PMID 22593206
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