YNL292W
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| Systematic name | YNL292W |
| Gene name | PUS4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:82806..84017 |
| Primary SGDID | S000005236 |
Description of YNL292W: Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)[1][2]
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References
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- ↑ Becker HF, et al. (1997) The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs. Nucleic Acids Res 25(22):4493-9 SGD PMID 9358157
- ↑ Qiu H, et al. (2000) Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol 20(7):2505-16 SGD PMID 10713174
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