YNL241C

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Systematic name YNL241C
Gene name ZWF1
Aliases MET19, POS10
Feature type ORF, Verified
Coordinates Chr XIV:197943..196426
Primary SGDID S000005185


Description of YNL241C: Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia[1][2][3][4]




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References

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  1. Blank LM, et al. (2005) Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast. Genome Biol 6(6):R49 SGD PMID 15960801
  2. Grabowska D, et al. (2004) A novel mutation in the glucose-6-phosphate dehydrogenase gene in a subject with chronic nonspherocytic hemolytic anemia--characterization of enzyme using yeast expression system and molecular modeling. Blood Cells Mol Dis 32(1):124-30 SGD PMID 14757426
  3. Izawa S, et al. (1998) Importance of glucose-6-phosphate dehydrogenase in the adaptive response to hydrogen peroxide in Saccharomyces cerevisiae. Biochem J 330 ( Pt 2)():811-7 SGD PMID 9480895
  4. Nogae I and Johnston M (1990) Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase. Gene 96(2):161-9 SGD PMID 2269430

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