YNL128W

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Systematic name YNL128W
Gene name TEP1
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:382359..383663
Primary SGDID S000005072


Description of YNL128W: PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1[1][2][3][4]




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References

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  1. Heymont J, et al. (2000) TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Proc Natl Acad Sci U S A 97(23):12672-7 SGD PMID 11070083
  2. Maehama T, et al. (2001) PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem 70():247-79 SGD PMID 11395408
  3. Mitra P, et al. (2004) A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol 166(2):205-11 SGD PMID 15249580
  4. Rodriguez-Escudero I, et al. (2005) Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J 390(Pt 2):613-23 SGD PMID 15913452

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