YNL116W
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| Systematic name | YNL116W |
| Gene name | DMA2 |
| Aliases | CHF2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:408341..409909 |
| Primary SGDID | S000005060 |
Description of YNL116W: Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains[1][2][3][4][5][6]
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References
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- Jump up ↑ Bieganowski P, et al. (2004) Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. J Biol Chem 279(43):44656-66 SGD PMID 15319434
- Jump up ↑ Fraschini R, et al. (2004) Functional characterization of Dma1 and Dma2, the budding yeast homologues of Schizosaccharomyces pombe Dma1 and human Chfr. Mol Biol Cell 15(8):3796-810 SGD PMID 15146058
- Jump up ↑ Loring GL, et al. (2008) Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination. Cell Cycle 7(1):96-105 SGD PMID 18202552
- Jump up ↑ Merlini L, et al. (2012) Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the elm1 kinase to the bud neck. PLoS Genet 8(4):e1002670 SGD PMID 22570619
- Jump up ↑ Raspelli E, et al. (2011) Budding yeast Dma1 and Dma2 participate in regulation of Swe1 levels and localization. Mol Biol Cell () SGD PMID 21562220
- Jump up ↑ Tuttle RL, et al. (2007) Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network. Mol Cancer Res 5(12):1304-11 SGD PMID 18171988
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