YNL088W

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Systematic name YNL088W
Gene name TOP2
Aliases TOR3, TRF3
Feature type ORF, Verified
Coordinates Chr XIV:457704..461990
Primary SGDID S000005032


Description of YNL088W: Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis[1][2][3][4]




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References

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  1. Goto T and Wang JC (1984) Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Cell 36(4):1073-80 SGD PMID 6323017
  2. Klein F, et al. (1992) Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. J Cell Biol 117(5):935-48 SGD PMID 1315786
  3. Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
  4. Wang JC (1996) DNA topoisomerases. Annu Rev Biochem 65:635-92 SGD PMID 8811192

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