YMR296C

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Systematic name YMR296C
Gene name LCB1
Aliases END8, TSC2
Feature type ORF, Verified
Coordinates Chr XIII:860891..859215
Primary SGDID S000004911


Description of YMR296C: Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine[1][2]




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References

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  1. Buede R, et al. (1991) Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J Bacteriol 173(14):4325-32 SGD PMID 2066332
  2. Nagiec MM, et al. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A 91(17):7899-902 SGD PMID 8058731

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