YMR228W
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| Systematic name | YMR228W |
| Gene name | MTF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:724626..725651 |
| Primary SGDID | S000004841 |
Description of YMR228W: Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation[1][2][3][4][5]
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References
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- Jump up ↑ Mangus DA, et al. (1994) Release of the yeast mitochondrial RNA polymerase specificity factor from transcription complexes. J Biol Chem 269(42):26568-74 SGD PMID 7929382
- Jump up ↑ Matsunaga M and Jaehning JA (2004) Intrinsic promoter recognition by a core RNA polymerase. J Biol Chem 279(43):44239-42 SGD PMID 15342628
- Jump up ↑ Schubot FD, et al. (2001) Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci 10(10):1980-8 SGD PMID 11567089
- Jump up ↑ Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () SGD PMID 21911502
- Jump up ↑ Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () SGD PMID 22524540
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