YMR023C

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Systematic name YMR023C
Gene name MSS1
Aliases PET53
Feature type ORF, Verified
Coordinates Chr XIII:321017..319437
Primary SGDID S000004625


Description of YMR023C: Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3[1][2][3][4]




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References

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  1. Colby G, et al. (1998) MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. J Biol Chem 273(43):27945-52 SGD PMID 9774408
  2. Decoster E, et al. (1993) MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. J Mol Biol 232(1):79-88 SGD PMID 8392589
  3. Li X and Guan MX (2002) A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation. Mol Cell Biol 22(21):7701-11 SGD PMID 12370316
  4. Umeda N, et al. (2005) Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem 280(2):1613-24 SGD PMID 15509579

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