YMR020W

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Systematic name YMR020W
Gene name FMS1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:315377..316903
Primary SGDID S000004622


Description of YMR020W: Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis[1][2][3]




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References

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  1. Chattopadhyay MK, et al. (2003) Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Proc Natl Acad Sci U S A 100(24):13869-74 SGD PMID 14617780
  2. Landry J and Sternglanz R (2003) Yeast Fms1 is a FAD-utilizing polyamine oxidase. Biochem Biophys Res Commun 303(3):771-6 SGD PMID 12670477
  3. White WH, et al. (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800 SGD PMID 11154694

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