YML130C
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| Systematic name | YML130C |
| Gene name | ERO1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:13174..11483 |
| Primary SGDID | S000004599 |
Description of YML130C: Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds[1][2][3][4]
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References
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- ↑ Frand AR and Kaiser CA (1998) The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum. Mol Cell 1(2):161-70 SGD PMID 9659913
- ↑ Gross E, et al. (2006) Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p. Proc Natl Acad Sci U S A 103(2):299-304 SGD PMID 16407158
- ↑ Kim S, et al. (2012) Balanced Ero1 activation and inactivation establishes ER redox homeostasis. J Cell Biol 196(6):713-25 SGD PMID 22412017
- ↑ Pollard MG, et al. (1998) Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell 1(2):171-82 SGD PMID 9659914
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