YML060W
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| Systematic name | YML060W |
| Gene name | OGG1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:151871..153001 |
| Primary SGDID | S000004525 |
Description of YML060W: Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance[1][2][3][4][5]
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S. cerevisiae OGG1 gene was first cloned by functional complementation of E.coli fpg mutY double mutant. However, there is no obvious sequence homology betweeen these two proteins. The Ogg1 protein is conserved in eukaryotes, from yeat to mammals.
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References
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- ↑ Kozmin S, et al. (2005) UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 102(38):13538-43 SGD PMID 16157879
- ↑ Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80 SGD PMID 8805338
- ↑ Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 SGD PMID 9358166
- ↑ Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 SGD PMID 11239005
- ↑ van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202 SGD PMID 8643552
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References
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