YLR437C

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Systematic name YLR437C
Gene name DIF1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:1012023..1011622
Primary SGDID S000004429


Description of YLR437C: Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein[1][2]




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References

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  1. Lee YD, et al. (2008) Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Mol Cell 32(1):70-80 SGD PMID 18851834
  2. Wu X and Huang M (2008) Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the r2 subunit. Mol Cell Biol 28(23):7156-67 SGD PMID 18838542

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