YLR409C
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| Systematic name | YLR409C |
| Gene name | UTP21 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:937233..934414 |
| Primary SGDID | S000004401 |
Description of YLR409C: Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma[1][2][3][4][5]
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References
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- ↑ Bernstein KA, et al. (2004) The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell 3(6):1619-26 SGD PMID 15590835
- ↑ Flom G, et al. (2005) Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNA helicase in Saccharomyces cerevisiae. Curr Genet 47(6):368-80 SGD PMID 15871019
- ↑ Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 SGD PMID 12150911
- ↑ Perez-Fernandez J, et al. (2007) The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol 27(15):5414-29 SGD PMID 17515605
- ↑ Skarie JM and Link BA (2008) The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. Hum Mol Genet 17(16):2474-85 SGD PMID 18469340
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