YLR386W
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| Systematic name | YLR386W |
| Gene name | VAC14 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:893628..896270 |
| Primary SGDID | S000004378 |
Description of YLR386W: Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p[1][2][3]
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References
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- ↑ Bonangelino CJ, et al. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol 156(6):1015-28 SGD PMID 11889142
- ↑ Dove SK, et al. (2002) Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body. Curr Biol 12(11):885-93 SGD PMID 12062051
- ↑ Rudge SA, et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15(1):24-36 SGD PMID 14528018
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