YLR265C

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Systematic name YLR265C
Gene name NEJ1
Aliases LIF2
Feature type ORF, Verified
Coordinates Chr XII:675455..674427
Primary SGDID S000004255


Description of YLR265C: Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p[1][2][3][4]




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References

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  1. Deshpande RA and Wilson TE (2007) Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4. DNA Repair (Amst) 6(10):1507-16 SGD PMID 17567543
  2. Frank-Vaillant M and Marcand S (2001) NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway. Genes Dev 15(22):3005-12 SGD PMID 11711435
  3. Kegel A, et al. (2001) Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr Biol 11(20):1611-7 SGD PMID 11676923
  4. Valencia M, et al. (2001) NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature 414(6864):666-9 SGD PMID 11740566

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