YLR223C

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Systematic name YLR223C
Gene name IFH1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:585490..582233
Primary SGDID S000004213


Description of YLR223C: Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]





References

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  1. Cherel I and Thuriaux P (1995) The IFH1 gene product interacts with a fork head protein in Saccharomyces cerevisiae. Yeast 11(3):261-70 SGD PMID 7785326
  2. Martin DE, et al. (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119(7):969-79 SGD PMID 15620355
  3. Rudra D, et al. (2007) Potential interface between ribosomal protein production and pre-rRNA processing. Mol Cell Biol 27(13):4815-24 SGD PMID 17452446
  4. Schawalder SB, et al. (2004) Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1. Nature 432(7020):1058-61 SGD PMID 15616569
  5. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  6. submitted by Jeff Ubersax on 2004-01-29

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