YLR113W

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Systematic name YLR113W
Gene name HOG1
Aliases SSK3
Feature type ORF, Verified
Coordinates Chr XII:371620..372927
Primary SGDID S000004103


Description of YLR113W: Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p[1][2][3][4][5][6]




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References

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  1. Alepuz PM, et al. (2003) Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II. EMBO J 22(10):2433-42 SGD PMID 12743037
  2. Brewster JL, et al. (1993) An osmosensing signal transduction pathway in yeast. Science 259(5102):1760-3 SGD PMID 7681220
  3. Cook KE and O'Shea EK (2012) Hog1 Controls Global Reallocation of RNA Pol II upon Osmotic Shock in Saccharomyces cerevisiae. G3 (Bethesda) 2(9):1129-36 SGD PMID 22973550
  4. Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 SGD PMID 21576396
  5. Mattison CP and Ota IM (2000) Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev 14(10):1229-35 SGD PMID 10817757
  6. O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 SGD PMID 12052881

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