YLR106C

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Systematic name YLR106C
Gene name MDN1
Aliases REA1
Feature type ORF, Verified
Coordinates Chr XII:363738..349006
Primary SGDID S000004096


Description of YLR106C: Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus[1][2][3][4]




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References

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  1. Bassler J, et al. (2010) The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly. Mol Cell 38(5):712-21 SGD PMID 20542003
  2. Garbarino J and Gibbons I (2002) Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. BMC Genomics 3(1):18 SGD PMID 12102729
  3. Nissan TA, et al. (2004) A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol Cell 15(2):295-301 SGD PMID 15260980
  4. Ulbrich C, et al. (2009) Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits. Cell 138(5):911-22 SGD PMID 19737519

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