YLR103C

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Systematic name YLR103C
Gene name CDC45
Aliases SLD4
Feature type ORF, Verified
Coordinates Chr XII:345941..343989
Primary SGDID S000004093


Description of YLR103C: DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes[1][2]




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References

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  1. ↑ McKie JM, et al. (1998) Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res 8(8):834-41 SGD PMID 9724329
  2. ↑ Tye BK (1999) MCM proteins in DNA replication. Annu Rev Biochem 68:649-86 SGD PMID 10872463

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