YLR089C

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Systematic name YLR089C
Gene name ALT1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:320015..318237
Primary SGDID S000004079


Description of YLR089C: Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive[1][2][3][4]




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References

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  1. Blank LM, et al. (2005) Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts. FEMS Yeast Res 5(6-7):545-58 SGD PMID 15780654
  2. Garcia-Campusano F, et al. (2009) ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae. Can J Microbiol 55(4):368-74 SGD PMID 19396236
  3. Penalosa-Ruiz G, et al. (2012) Paralogous ALT1 and ALT2 Retention and Diversification Have Generated Catalytically Active and Inactive Aminotransferases in Saccharomyces cerevisiae. PLoS One 7(9):e45702 SGD PMID 23049841
  4. Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961

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