YLR058C
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| Systematic name | YLR058C |
| Gene name | SHM2 |
| Aliases | SHMT2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:259401..257992 |
| Primary SGDID | S000004048 |
Description of YLR058C: Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis[1][2]
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References
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- Jump up ↑ Kastanos EK, et al. (1997) Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry 36(48):14956-64 SGD PMID 9398220
- Jump up ↑ McNeil JB, et al. (1994) Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. J Biol Chem 269(12):9155-65 SGD PMID 8132653
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