YLL039C

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Systematic name YLL039C
Gene name UBI4
Aliases SCD2, UB14
Feature type ORF, Verified
Coordinates Chr XII:65207..64062
Primary SGDID S000003962


Description of YLL039C: Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats[1][2][3][4][5][6]




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References

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  1. Finley D, et al. (1987) The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell 48(6):1035-46 SGD PMID 3030556
  2. Finley D, et al. (1994) Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol Cell Biol 14(8):5501-9 SGD PMID 8035826
  3. Lucero P, et al. (2000) Monoubiquitination is sufficient to signal internalization of the maltose transporter in Saccharomyces cerevisiae. J Bacteriol 182(1):241-3 SGD PMID 10613890
  4. Ozkaynak E, et al. (1984) The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein. Nature 312(5995):663-6 SGD PMID 6095120
  5. Ozkaynak E, et al. (1987) The yeast ubiquitin genes: a family of natural gene fusions. EMBO J 6(5):1429-39 SGD PMID 3038523
  6. Shih SC, et al. (2000) Monoubiquitin carries a novel internalization signal that is appended to activated receptors. EMBO J 19(2):187-98 SGD PMID 10637223

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