YKR084C

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Systematic name YKR084C
Gene name HBS1
Aliases
Feature type ORF, Verified
Coordinates Chr XI:598890..597055
Primary SGDID S000001792


Description of YKR084C: GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay[1][2][3][4][5]




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References

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  1. Carr-Schmid A, et al. (2002) Novel G-protein complex whose requirement is linked to the translational status of the cell. Mol Cell Biol 22(8):2564-74 SGD PMID 11909951
  2. Doma MK and Parker R (2006) Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation. Nature 440(7083):561-4 SGD PMID 16554824
  3. Nelson RJ, et al. (1992) The translation machinery and 70 kd heat shock protein cooperate in protein synthesis. Cell 71(1):97-105 SGD PMID 1394434
  4. Passos DO, et al. (2009) Analysis of Dom34 and its function in no-go decay. Mol Biol Cell 20(13):3025-32 SGD PMID 19420139
  5. Shoemaker CJ, et al. (2010) Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science 330(6002):369-72 SGD PMID 20947765

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