YKR019C
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| Systematic name | YKR019C |
| Gene name | IRS4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:478063..476216 |
| Primary SGDID | S000001727 |
Description of YKR019C: EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS[1][2][3]
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References
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- ↑ Bugnicourt A, et al. (2008) Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Traffic 9(5):755-69 SGD PMID 18298591
- ↑ Paoluzi S, et al. (1998) Recognition specificity of individual EH domains of mammals and yeast. EMBO J 17(22):6541-50 SGD PMID 9822599
- ↑ Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 SGD PMID 10082585
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