YKL184W
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| Systematic name | YKL184W |
| Gene name | SPE1 |
| Aliases | ORD1, SPE10 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:96757..98157 |
| Primary SGDID | S000001667 |
Description of YKL184W: Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation[1][2][3][4]
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References
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- ↑ Eisenberg T, et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-14 SGD PMID 19801973
- ↑ Fonzi WA (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase. Biochem Biophys Res Commun 162(3):1409-16 SGD PMID 2669750
- ↑ Fonzi WA and Sypherd PS (1987) The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem 262(21):10127-33 SGD PMID 3038869
- ↑ Toth C and Coffino P (1999) Regulated degradation of yeast ornithine decarboxylase. J Biol Chem 274(36):25921-6 SGD PMID 10464336
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