YKL141W

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Systematic name YKL141W
Gene name SDH3
Aliases CYB3, YKL4
Feature type ORF, Verified
Coordinates Chr XI:179667..180263
Primary SGDID S000001624


Description of YKL141W: Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex[1][2]




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References

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  1. Gebert N, et al. (2011) Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane. Mol Cell 44(5):811-8 SGD PMID 22152483
  2. Oyedotun KS and Lemire BD (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279(10):9424-31 SGD PMID 14672929

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