YKL125W
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| Systematic name | YKL125W |
| Gene name | RRN3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:208247..210130 |
| Primary SGDID | S000001608 |
Description of YKL125W: Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo[1][2][3]
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References
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- ↑ Blattner C, et al. (2011) Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes Dev () SGD PMID 21940764
- ↑ Peyroche G, et al. (2000) The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3. EMBO J 19(20):5473-82 SGD PMID 11032814
- ↑ Yamamoto RT, et al. (1996) RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J 15(15):3964-73 SGD PMID 8670901
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