YKL004W

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Systematic name YKL004W
Gene name AUR1
Aliases
Feature type ORF, Verified
Coordinates Chr XI:435580..436785
Primary SGDID S000001487


Description of YKL004W: Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance[1][2]




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References

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  1. Heidler SA and Radding JA (1995) The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337). Antimicrob Agents Chemother 39(12):2765-9 SGD PMID 8593016
  2. Nagiec MM, et al. (1997) Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem 272(15):9809-17 SGD PMID 9092515

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