YJR122W

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Systematic name YJR122W
Gene name IBA57
Aliases CAF17
Feature type ORF, Verified
Coordinates Chr X:649776..651269
Primary SGDID S000003883


Description of YJR122W: Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system[1][2]




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References

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  1. Clark LB, et al. (2004) Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. J Biol Chem 279(14):13616-23 SGD PMID 14734555
  2. Gelling C, et al. (2008) Mitochondrial Iba57p Is Required for Fe/S Cluster Formation on Aconitase and Activation of Radical SAM Enzymes. Mol Cell Biol 28(5):1851-1861 SGD PMID 18086897

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