YJR069C
Share your knowledge...Edit this entry! <protect>
| Systematic name | YJR069C |
| Gene name | HAM1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:569399..568806 |
| Primary SGDID | S000003830 |
Description of YJR069C: Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine[1][2][3][4][5]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
<protect>
References
See Help:References on how to add references
- ↑ Burgis NE and Cunningham RP (2007) Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem 282(6):3531-8 SGD PMID 17090528
- ↑ Davies O, et al. (2012) Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism. BMB Rep 45(4):259-64 SGD PMID 22531138
- ↑ Noskov VN, et al. (1996) HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. Yeast 12(1):17-29 SGD PMID 8789257
- ↑ Pang B, et al. (2012) Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proc Natl Acad Sci U S A () SGD PMID 22308425
- ↑ Takayama S, et al. (2007) Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Curr Genet 52(5-6):203-11 SGD PMID 17899088
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
