YJR008W
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| Systematic name | YJR008W |
| Gene name | MHO1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:452430..453446 |
| Primary SGDID | S000003768 |
Description of YJR008W: Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility[1][2][3][4][5]
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References
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- Jump up ↑ Gasch AP, et al. (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11(12):4241-57 SGD PMID 11102521
- Jump up ↑ Jin R, et al. (2008) Large-scale analysis of yeast filamentous growth by systematic gene disruption and overexpression. Mol Biol Cell 19(1):284-96 SGD PMID 17989363
- Jump up ↑ Sakaki K, et al. (2003) Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae. J Biochem 134(3):373-84 SGD PMID 14561723
- Jump up ↑ Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30 SGD PMID 12871953
- Jump up ↑ Schlatter ID, et al. (2012) MHO1, an Evolutionarily Conserved Gene, Is Synthetic Lethal with PLC1; Mho1p Has a Role in Invasive Growth. PLoS One 7(3):e32501 SGD PMID 22412880
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