YIL146C
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| Systematic name | YIL146C |
| Gene name | ATG32 |
| Aliases | ECM37 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:75773..74184 |
| Primary SGDID | S000001408 |
Description of YIL146C: Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane[1][2][3]
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References
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- ↑ Kanki T, et al. (2009) Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell 17(1):98-109 SGD PMID 19619495
- ↑ Kondo-Okamoto N, et al. (2012) Autophagy-related protein 32 acts as an autophagic degron and directly initiates mitophagy. J Biol Chem () SGD PMID 22308029
- ↑ Okamoto K, et al. (2009) Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 17(1):87-97 SGD PMID 19619494
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