YHR170W

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Systematic name YHR170W
Gene name NMD3
Aliases SRC5
Feature type ORF, Verified
Coordinates Chr VIII:443828..445384
Primary SGDID S000001213


Description of YHR170W: Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex[1][2]




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Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [3] [4]





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References

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  1. Ho JH and Johnson AW (1999) NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2389-99 SGD PMID 10022925
  2. Ho JH, et al. (2000) Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J Cell Biol 151(5):1057-66 SGD PMID 11086007
  3. He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
  4. submitted by Jurgen Wittmann on 2003-04-30

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