YHR111W
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| Systematic name | YHR111W |
| Gene name | UBA4 |
| Aliases | YHR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:333072..334394 |
| Primary SGDID | S000001153 |
Description of YHR111W: Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p[1][2][3][4]
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References
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- ↑ Goehring AS, et al. (2003) Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Eukaryot Cell 2(5):930-6 SGD PMID 14555475
- ↑ Goehring AS, et al. (2003) Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Mol Biol Cell 14(11):4329-41 SGD PMID 14551258
- ↑ Leidel S, et al. (2009) Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 458(7235):228-32 SGD PMID 19145231
- ↑ Noma A, et al. (2009) Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. Nucleic Acids Res 37(4):1335-52 SGD PMID 19151091
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