YHR013C
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| Systematic name | YHR013C |
| Gene name | ARD1 |
| Aliases | NAA10 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:131446..130730 |
| Primary SGDID | S000001055 |
Description of YHR013C: Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells[1][2][3][4][5]
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Community Commentary
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Mutations in ARD1 lead to inability to respond to alpha-factor, inability to enter stationary phase, and inability to sporulate [6] [7]
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References
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- ↑ Gautschi M, et al. (2003) The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol Cell Biol 23(20):7403-14 SGD PMID 14517307
- ↑ Mullen JR, et al. (1989) Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J 8(7):2067-75 SGD PMID 2551674
- ↑ Park EC and Szostak JW (1992) ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J 11(6):2087-93 SGD PMID 1600941
- ↑ Polevoda B and Sherman F (2003) Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem Biophys Res Commun 308(1):1-11 SGD PMID 12890471
- ↑ Yu M, et al. (2009) Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo. Oncol Rep 21(4):909-15 SGD PMID 19287988
- ↑ Whiteway M and Szostak JW (1985) The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell 43(2 Pt 1):483-92 SGD PMID 3907857
- ↑ submitted by Juanita Martinez on 2004-09-22
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