YHL023C
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| Systematic name | YHL023C |
| Gene name | NPR3 |
| Aliases | RMD11 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:62563..59123 |
| Primary SGDID | S000001015 |
Description of YHL023C: Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair[1][2][3][4][5]
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References
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- Jump up ↑ Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics () SGD PMID 21454883
- Jump up ↑ Enyenihi AH and Saunders WS (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54 SGD PMID 12586695
- Jump up ↑ Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 SGD PMID 18069899
- Jump up ↑ Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515 SGD PMID 19521502
- Jump up ↑ Wu X and Tu BP (2011) Selective Regulation of Autophagy by the Iml1p-Npr2p-Npr3p Complex in the Absence of Nitrogen Starvation. Mol Biol Cell () SGD PMID 21900499
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