YGR231C

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Systematic name YGR231C
Gene name PHB2
Aliases
Feature type ORF, Verified
Coordinates Chr VII:953480..952548
Primary SGDID S000003463


Description of YGR231C: Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation[1][2][3][4][5]




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References

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  1. Berger KH and Yaffe MP (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18(7):4043-52 SGD PMID 9632789
  2. Coates PJ, et al. (1997) The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr Biol 7(8):607-10 SGD PMID 9259555
  3. Nijtmans LG, et al. (2000) Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19(11):2444-51 SGD PMID 10835343
  4. Piper PW, et al. (2002) The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1(2):149-57 SGD PMID 12882345
  5. Tatsuta T, et al. (2005) Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell 16(1):248-59 SGD PMID 15525670

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