YGR222W

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Systematic name YGR222W
Gene name PET54
Aliases
Feature type ORF, Verified
Coordinates Chr VII:939923..940804
Primary SGDID S000003454


Description of YGR222W: Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing[1][2][3][4]




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References

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  1. Costanzo MC, et al. (1989) The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics 122(2):297-305 SGD PMID 2548921
  2. Kaspar BJ, et al. (2008) A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria. Nucleic Acids Res 36(9):2958-68 SGD PMID 18388132
  3. Naithani S, et al. (2003) Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell 14(1):324-33 SGD PMID 12529447
  4. Valencik ML, et al. (1989) Disruption of the yeast nuclear PET54 gene blocks excision of mitochondrial intron aI5 beta from pre-mRNA for cytochrome c oxidase subunit I. EMBO J 8(12):3899-904 SGD PMID 2555177

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