YGR175C

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Systematic name YGR175C
Gene name ERG1
Aliases
Feature type ORF, Verified
Coordinates Chr VII:848423..846933
Primary SGDID S000003407


Description of YGR175C: Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine[1][2]




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References

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  1. Jandrositz A, et al. (1991) The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization. Gene 107(1):155-60 SGD PMID 1743514
  2. Satoh T, et al. (1993) Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae. Biol Pharm Bull 16(4):349-52 SGD PMID 8358382

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