YGR155W
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| Systematic name | YGR155W |
| Gene name | CYS4 |
| Aliases | NHS5, STR4, VMA41 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:798543..800066 |
| Primary SGDID | S000003387 |
Description of YGR155W: Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria[1][2][3][4][5]
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References
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- ↑ Hoose SA, et al. (2012) A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet 8(3):e1002590 SGD PMID 22438835
- ↑ Ono B, et al. (1988) Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency. J Bacteriol 170(12):5883-9 SGD PMID 3056921
- ↑ Ono B, et al. (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9 SGD PMID 8017103
- ↑ Shan X and Kruger WD (1998) Correction of disease-causing CBS mutations in yeast. Nat Genet 19(1):91-3 SGD PMID 9590298
- ↑ Singh S, et al. (2009) Relative Contributions of Cystathionine {beta}-Synthase and {gamma}-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions. J Biol Chem 284(33):22457-66 SGD PMID 19531479
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