YGR123C
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| Systematic name | YGR123C |
| Gene name | PPT1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:738203..736662 |
| Primary SGDID | S000003355 |
Description of YGR123C: Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth[1][2][3][4][5]
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References
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- ↑ Chen MX, et al. (1994) A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J 13(18):4278-90 SGD PMID 7925273
- ↑ Jeong JY, et al. (2003) Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5. BMC Cell Biol 4():3 SGD PMID 12694636
- ↑ Soroka J, et al. (2012) Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation. Mol Cell 45(4):517-28 SGD PMID 22365831
- ↑ Vaughan CK, et al. (2008) Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell 31(6):886-95 SGD PMID 18922470
- ↑ Wandinger SK, et al. (2006) The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90. EMBO J 25(2):367-76 SGD PMID 16407978
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