YGR098C
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| Systematic name | YGR098C |
| Gene name | ESP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:687458..682566 |
| Primary SGDID | S000003330 |
Description of YGR098C: Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p[1][2][3]
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References
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- Jump up ↑ Ciosk R, et al. (1998) An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93(6):1067-76 SGD PMID 9635435
- Jump up ↑ Queralt E, et al. (2006) Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125(4):719-32 SGD PMID 16713564
- Jump up ↑ Uhlmann F, et al. (2000) Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell 103(3):375-86 SGD PMID 11081625
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