YGR062C

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Systematic name YGR062C
Gene name COX18
Aliases OXA2
Feature type ORF, Verified
Coordinates Chr VII:617278..616328
Primary SGDID S000003294


Description of YGR062C: Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC[1][2][3][4][5]




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References

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  1. Jump up Fiumera HL, et al. (2007) Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Mol Cell Biol 27(13):4664-73 SGD PMID 17452441
  2. Jump up Fiumera HL, et al. (2009) Translocation and Assembly of Mitochondrially Coded Saccharomyces cerevisiae Cytochrome c Oxidase Subunit Cox2 by Oxa1 and Yme1 in the Absence of Cox18. Genetics 182(2):519-28 SGD PMID 19307606
  3. Jump up Saracco SA and Fox TD (2002) Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell 13(4):1122-31 SGD PMID 11950926
  4. Jump up Souza RL, et al. (2000) Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase. J Biol Chem 275(20):14898-902 SGD PMID 10809734
  5. Jump up van Bloois E, et al. (2007) Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC. FEBS J 274(21):5704-13 SGD PMID 17922846

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