YGL246C

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Systematic name YGL246C
Gene name RAI1
Aliases
Feature type ORF, Verified
Coordinates Chr VII:38780..37617
Primary SGDID S000003215


Description of YGL246C: Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z[1][2][3]




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References

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  1. Jiao X, et al. (2010) Identification of a quality-control mechanism for mRNA 5'-end capping. Nature 467(7315):608-11 SGD PMID 20802481
  2. Sydorskyy Y, et al. (2003) Intersection of the Kap123p-mediated nuclear import and ribosome export pathways. Mol Cell Biol 23(6):2042-54 SGD PMID 12612077
  3. Xue Y, et al. (2000) Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p. Mol Cell Biol 20(11):4006-15 SGD PMID 10805743

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