YGL194C
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| Systematic name | YGL194C |
| Gene name | HOS2 |
| Aliases | RTL1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:141726..140368 |
| Primary SGDID | S000003162 |
Description of YGL194C: Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS[1][2][3][4]
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References
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- ↑ Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 SGD PMID 11711434
- ↑ Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 SGD PMID 12086601
- ↑ Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
- ↑ Wang A, et al. (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4 SGD PMID 12434058
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