YGL190C
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| Systematic name | YGL190C |
| Gene name | CDC55 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:147389..145809 |
| Primary SGDID | S000003158 |
Description of YGL190C: Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion[1][2][3][4][5][6]
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References
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- Jump up ↑ Bizzari F and Marston AL (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol () SGD PMID 21690308
- Jump up ↑ Gentry MS and Hallberg RL (2002) Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol Biol Cell 13(10):3477-92 SGD PMID 12388751
- Jump up ↑ Jiang Y and Broach JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J 18(10):2782-92 SGD PMID 10329624
- Jump up ↑ Queralt E, et al. (2006) Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125(4):719-32 SGD PMID 16713564
- Jump up ↑ Rossio V and Yoshida S (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54 SGD PMID 21536748
- Jump up ↑ Wang Y and Burke DJ (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6 SGD PMID 9001215
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