YGL133W

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Systematic name YGL133W
Gene name ITC1
Aliases
Feature type ORF, Verified
Coordinates Chr VII:257707..261501
Primary SGDID S000003101


Description of YGL133W: Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex[1][2][3][4]




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References

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  1. Brestovitsky A, et al. (2011) The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes. Nucleic Acids Res () SGD PMID 21546548
  2. Goldmark JP, et al. (2000) The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell 103(3):423-33 SGD PMID 11081629
  3. Ruiz C, et al. (2003) Cell-type-dependent repression of yeast a-specific genes requires Itc1p, a subunit of the Isw2p-Itc1p chromatin remodelling complex. Microbiology 149(Pt 2):341-51 SGD PMID 12624196
  4. Sugiyama M and Nikawa J (2001) The Saccharomyces cerevisiae Isw2p-Itc1p complex represses INO1 expression and maintains cell morphology. J Bacteriol 183(17):4985-93 SGD PMID 11489850

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